Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis
| Autor: | L. Sueri, B. Milanesi, R. Ciammarughi, G. P. Cadeo, M. Tosi, P. Peretti |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Cefotaxime Adolescent medicine.drug_class Antibiotics Blood–brain barrier Gastroenterology Agar plate Cerebrospinal fluid Internal medicine Humans Medicine Meningitis Pharmacology (medical) Child CSF albumin Pharmacology business.industry Albumin Bacterial Infections Middle Aged medicine.disease Infectious Diseases medicine.anatomical_structure business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 14:117-123 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/14.suppl_b.117 |
| Popis: | Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum. |
| Databáze: | OpenAIRE |
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