Low thyroid function is not associated with an accelerated deterioration in renal function
| Autor: | Douglas C. Bauer, Anton J. M. de Craen, Giorgio Iervasi, Patricia M. Kearney, Alexandra Bremner, Graziano Ceresini, José Augusto Sgarbi, Bert Vaes, Friedo W. Dekker, Rui M. B. Maciel, Michael G. Shlipak, Sabrina Molinaro, J. Wouter Jukema, Merel van Diepen, Stella Trompet, Trine Bjøro, Waka Ohishi, Bjørn Olav Åsvold, Wendy P. J. den Elzen, Robin P. Peeters, Henry Völzke, Massimo Iacoviello, Kay-Tee Khaw, Anne R. Cappola, Mark J. Sarnak, Stephan J. L. Bakker, Christiaan L. Meuwese, Oscar H. Franco, Lars J. Vatten, Nicolas Rodondi, Luigi Ferrucci, Jacobijn Gussekloo, Misa Imaizumi, Linda P. Fried, Robert Luben, David J. Stott, John P. Walsh, Robin P. F. Dullaart, Jean Degryse |
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| Přispěvatelé: | Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Epidemiology, Internal Medicine |
| Rok vydání: | 2018 |
| Předmět: |
Male
CHRONIC KIDNEY-DISEASE NONTHYROIDAL ILLNESS Kidney Disease endocrine system diseases 030232 urology & nephrology Thyroid Function Tests 030204 cardiovascular system & hematology GLOMERULAR-FILTRATION-RATE Gastroenterology chemistry.chemical_compound SUBCLINICAL HYPOTHYROIDISM 0302 clinical medicine creatinine clearance 80 and over Euthyroid Longitudinal Studies Renal Insufficiency Chronic 610 Medicine & health Netherlands Aged 80 and over medicine.diagnostic_test Incidence CARDIOVASCULAR RISK Thyroid Middle Aged Urology & Nephrology OLDER PERSONS Prognosis medicine.anatomical_structure Nephrology HEART-FAILURE Female epidemiology Thyroid function Life Sciences & Biomedicine 360 Social problems & social services Glomerular Filtration Rate Thyroid Hormones medicine.medical_specialty Clinical Sciences Renal and urogenital Renal function Thyroid function tests 03 medical and health sciences Meta-Analysis as Topic Thyroid-stimulating hormone Clinical Research chronic renal failure Internal medicine CKD medicine Humans Renal Insufficiency Chronic Metabolic and endocrine Aged Transplantation Creatinine Science & Technology SERUM CREATININE thyroid function business.industry HORMONE REPLACEMENT THERAPY Thyroid Studies Collaboration medicine.disease Thyroid Diseases Cross-Sectional Studies chemistry RISK-FACTORS ORIGINAL ARTICLES business Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, vol 34, iss 4 Nephrology, Dialysis, Transplantation, 34(4), 650-659. Oxford University Press Nephrology, dialysis, transplantation, 34(4), 650-659 Nephrology Dialysis Transplantation, 34(4), 650-659 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models. Results A total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval) −4.07 (−6.37 to −1.78) and −2.40 (−3.78 to −1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50–4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function. Conclusions Low thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations. |
| Databáze: | OpenAIRE |
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