Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study
| Autor: | Yu-Jing Fang, Alinuer Abulimiti, Xin Zhang, Hong Luo, Nai-Qi Zhang, Xiao-Li Feng, Chu-Yi Huang, Cai-Xia Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
0301 basic medicine Selenium intake Cancer Research China Colorectal cancer Medicine (miscellaneous) chemistry.chemical_element Physiology Zinc medicine.disease_cause Polymorphism Single Nucleotide Dietary zinc 03 medical and health sciences Selenium 0302 clinical medicine Risk Factors Medicine Humans Chinese population 030109 nutrition & dietetics Nutrition and Dietetics business.industry Case-control study food and beverages medicine.disease Diet Oxidative Stress Logistic Models Oncology chemistry 030220 oncology & carcinogenesis Case-Control Studies business Colorectal Neoplasms Oxidative stress |
| Zdroj: | Nutrition and cancer. 73(9) |
| ISSN: | 1532-7914 |
| Popis: | Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total of 493 cases and 498 sex and age-matched controls were randomly selected from an ongoing case-control study. Dietary information was assessed through face-to-face interviews using a validated food frequency questionnaire. Multiplex PCR-ligase detection reaction was used for genotyping the target SNPs. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence interval (CI). Intake of selenium was found to be inversely associated with CRC risk, while zinc was not associated with CRC risk. The ORs (95% CI) for the highest |
| Databáze: | OpenAIRE |
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