Isolation and characterization of a new nucleoside antibiotic, amipurimycin
| Autor: | Toyokazu Kishi, Setsuo Harada |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
Pyricularia Natural product Chemical Phenomena Stereochemistry medicine.drug_class Antibiotics Nucleosides Riboside Biology biology.organism_classification Streptomyces In vitro Anti-Bacterial Agents Molecular Weight Chemistry chemistry.chemical_compound chemistry In vivo Drug Discovery medicine Nucleoside |
| Zdroj: | The Journal of Antibiotics. 30:11-16 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | A new antibiotic amipurimycin, active against Pyricularia oryzae in vitro and in vivo, was isolated from the culture filtrate of Streptomyces novoguineensis nov. sp. The antibiotic was purified by a combination of ion-exchange and adsorption chromatography based on its amphoteric water-soluble characteristics. Its molecular formula was estimated to be C20H27approximately31N7O8-H2O. Characteristic maxima in the UV spectrum and signals in the PMR and CMR spectra were similar to those of 2-aminopurine 9-(beta-D)-riboside. These findings indicated that amipurimycin is a new nucleoside antibiotic and the first example of a natural product containing 2-aminopurine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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