Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death
| Autor: | Silke Niemann, Janine J. Wilden, Bettina Löffler, Christina Ehrhardt, Stephan Ludwig, Georg Peters, Andre van Krüchten |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus 030106 microbiology Inflammation Apoptosis Biology Caspase 8 medicine.disease_cause Biochemistry Virus Microbiology Madin Darby Canine Kidney Cells 03 medical and health sciences Necrosis Dogs Influenza A Virus H1N1 Subtype Influenza Human Genetics medicine Human Umbilical Vein Endothelial Cells Animals Humans Viability assay Molecular Biology Cell damage Staphylococcal Infections medicine.disease 030104 developmental biology medicine.symptom Intracellular Biotechnology |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5) |
| ISSN: | 1530-6860 |
| Popis: | Superinfections with Staphylococcus aureus are a major complication of influenza disease, causing excessive inflammation and tissue damage. This enhanced cell-damaging effect is also observed in superinfected tissue cultures, leading to a strong decrease in overall cell viability. In our analysis of the underlying molecular mechanisms, we observed that, despite enhanced cell damage in superinfection, S. aureus did not increase but rather inhibited influenza virus (IV)-induced apoptosis in cells on the level of procaspase-8 activation. This apparent contradiction was solved when we observed that S. aureus mediated a switch from apoptosis to necrotic cell death of IV-infected cells, a mechanism that was dependent on the bacterial accessory gene regulator ( agr) locus that promotes bacterial survival and spread. This so far unknown action may be a bacterial strategy to enhance dissemination of intracellular S. aureus and may thereby contribute to increased tissue damage and severity of disease.-Van Kruchten, A., Wilden, J. J., Niemann, S., Peters, G., Loffler, B., Ludwig, S., Ehrhardt, C. Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death. |
| Databáze: | OpenAIRE |
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