Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
Autor: | Fangcai Li, Huanying Zheng, Fang Bo, Yan Wang, Peishan Lu, Yan Liu, Xiaodong Sun, Shengwei Wu, David Featherstone, Zhao-Hui Yang, Suyi Gu, Hong Tian, Chunyu Liu, Wei Tang, Jianhui Zhou, Songtao Xu, Yixin Ji, Yuan Si, Leng Liu, Paul A. Rota, Shuang Wang, Jiangtao Ma, Shujie Zhou, Jianfeng Liu, Youngmee Jee, Daxing Feng, Liwei Sun, Ying Hu, Huiling Wang, Yuyan Ma, Zhenying Zhang, Zhengrong Ding, Xueqiang Fang, Changyin Wang, Yan Zhang, Hui Gao, Wenbo Xu, Xiaojie Zhang, William J. Bellini, Yan Feng, Shunde Zhou, Zhen Zhu |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Viral Diseases
China Genes Viral Genotype Sequence analysis Epidemiology lcsh:Medicine Biology Measles Microbiology Infectious Disease Epidemiology Measles virus Virology medicine Humans Evolutionary Systematics lcsh:Science Gene Evolutionary Biology Molecular Epidemiology Multidisciplinary Population Biology Transmission (medicine) Incidence (epidemiology) Incidence lcsh:R Nucleic acid sequence medicine.disease biology.organism_classification Phylogenetics Infectious Diseases Medical Microbiology Population Surveillance Medicine lcsh:Q Viral Transmission and Infection Research Article |
Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 4, p e34401 (2012) |
ISSN: | 1932-6203 |
Popis: | The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%-100% and 84.7%-100%, H1b were 97.1%-100% and 95.3%-100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years. |
Databáze: | OpenAIRE |
Externí odkaz: |