| Autor: |
Seyed Yahya Rahnamaee, Seyed Mohsen Dehnavi, Reza Bagheri, Mahdi Barjasteh, Mortaza Golizadeh, Hedyeh Zamani, Afzal Karimi |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
International Journal of Biological Macromolecules. 228:570-581 |
| ISSN: |
0141-8130 |
| DOI: |
10.1016/j.ijbiomac.2022.12.159 |
| Popis: |
One of the most vital aspects of the orthopedic implant field has been the development of multifunctional coatings that improve bone-implant contact while simultaneously preventing bacterial infection. The present study investigates the fabrication and characterization of multifunctional polysaccharides, including carboxymethyl cellulose (CMCn) and carboxymethyl chitosan nanofibers (CMCHn), as a novel implant coating on titania nanotube arrays (T). Field emission scanning electron microscopy (FESEM) images revealed a nanofibrous morphology with a narrow diameter for CMCn and CMCHn, similar to extracellular matrix nanostructures. Compared to the T surface, the roughness of CMCn and CMCHn samples increased by over 250 %. An improved cell proliferation rate was observed on CMCHn nanofibers with a positively charged surface caused by the amino groups. Furthermore, in an antibacterial experiment, CMCn and CMCHn inhibited bacterial colony formation by 80 % and 73 %, respectively. According to the results, constructed modified CMCn and CMCHn increased osteoblast cell survival while inhibiting bacterial biofilm formation owing to their surface charge and bioinspired physicochemical properties. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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