Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study
| Autor: | Claudia Norambuena, Viviana Flores, Pamela Puentes, Patricia Carrasco, Rodolfo Villena, Jaqueline Yáñez V |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Sedation Midazolam Administration Oral law.invention Randomized controlled trial Double-Blind Method law medicine Humans Hypnotics and Sedatives Pain Management Ketamine Prospective Studies Prospective cohort study Analgesics business.industry Codeine Infant General Medicine Acetaminophen Surgery Anesthesia Pediatrics Perinatology and Child Health Drug Therapy Combination Female medicine.symptom business Burns Total body surface area medicine.drug |
| Zdroj: | Journal of pediatric surgery. 48(3) |
| ISSN: | 1531-5037 |
| Popis: | Purpose The aim of this study was to compare the efficacy of oral midazolam and ketamine with oral midazolam, acetaminophen, and codeine in providing sedation and analgesia for wound care procedures in children with burns. Methods This is a prospective, randomized, double-blind study that includes patients 1 to 5 years old hospitalized between 2010 and 2011, with burns covering up to 10% of total body surface area that required bedside wound care. Group 1 received oral midazolam (0.5 mg/kg) and ketamine (5 mg/ kg). Group 2 received oral midazolam (0.5 mg/kg), acetaminophen (10 mg/kg), and codeine (1 mg/kg). Sedation was assessed using the University of Michigan Sedation Scale and pain using the CHEOPS scale. Results Sixty patients were enrolled and evenly distributed into the two groups. There were a higher percentage of well-sedated patients in Group 1, but this was not statistically significant. Patients in Group 2 reported lower levels of pain (p = 0.0245). Adverse reactions were reported in both groups. The only parameter that had a statistical difference was nystagmus (p = 0.001). Conclusion The combination of oral midazolam and ketamine provides better analgesia than the combination of midazolam, acetaminophen, and codeine for painful procedures in burned children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect