Associations between urinary phthalate metabolites and bisphenol A levels, and serum thyroid hormones among the Korean adult population - Korean National Environmental Health Survey (KoNEHS) 2012–2014

Autor: Suejin Kim, Inae Lee, Moon-Young Hwang, Domyung Paek, Wookhee Choi, Kyungho Choi, Seung-Do Yu, Young-Mee Lee, Choong-Hee Park
Rok vydání: 2017
Předmět:
Adult
Male
Thyroid Hormones
endocrine system
medicine.medical_specialty
Environmental Engineering
Urinary system
Population
Phthalic Acids
030209 endocrinology & metabolism
Urine
010501 environmental sciences
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Phenols
Interquartile range
Surveys and Questionnaires
Internal medicine
Environmental health
Republic of Korea
medicine
Humans
Environmental Chemistry
Benzhydryl Compounds
education
Waste Management and Disposal
0105 earth and related environmental sciences
education.field_of_study
Triiodothyronine
Chemistry
Thyroid
Phthalate
Environmental Exposure
Pollution
Endocrinology
medicine.anatomical_structure
Environmental Pollutants
Female
hormones
hormone substitutes
and hormone antagonists
Hormone
Zdroj: Science of The Total Environment. :950-957
ISSN: 0048-9697
DOI: 10.1016/j.scitotenv.2017.01.144
Popis: Background Phthalates and bisphenol A (BPA) have been used extensively in many consumer products, resulting in widespread exposure in the general population. Studies have suggested associations between exposure to phthalates and BPA, and serum thyroid hormone levels, but confirmation on larger human populations is warranted. Methods Data obtained from nationally representative Korean adults (n = 6003) recruited for the second round of the Korean National Environmental Health Survey (KoNEHS), 2012–2014, were employed. Three di-(2-ethylhexyl) phthalate (DEHP) metabolites, along with benzyl-butyl phthalate (BBzP) and di-butyl phthalate (DBP) metabolites, and BPA were measured in subjects' urine. Thyroxine (T4), total triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were measured in serum. The associations between urinary phthalates or BPA and thyroid hormone levels were determined. Results Urinary phthalate metabolites were generally associated with lowered total T4 or T3, or increased TSH levels in serum. Interquartile range (IQR) increases of mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were associated with a 3.7% increase of TSH, and a 1.7% decrease of total T4 levels, respectively. When grouped by sex, urinary MEHHP levels were inversely associated with T4 only among males. Among females, mono-benzyl phthalate (MBzP) and mono- n -butyl phthalate (MnBP) levels were inversely associated with TSH and T3, respectively. In addition, negative association between BPA and TSH was observed. Conclusions Several phthalates and BPA exposures were associated with altered circulatory thyroid hormone levels among general Korean adult population. Considering the importance of thyroid hormones, public health implications of such alteration warrant further studies.
Databáze: OpenAIRE
Externí odkaz: