An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction
| Autor: | Jianjun Guan, Xuanyou Liu Liu, Ning Gao, Xinyu Zhou, Haichang Li, Chao Li, Pei-Hui Lin, Yu Dang, Yunyan Duan, Zhaobo Fan, Zhaobin Xu, Hong Niu, Jianjie Ma, Ya Guan, Xiaoyu Cui |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cardiac function curve medicine.medical_specialty Cell Survival Angiogenesis Myocardial Infarction lcsh:Medicine Neovascularization Physiologic chemistry.chemical_element 02 engineering and technology Oxygen Article Injections Neovascularization 03 medical and health sciences Internal medicine Human Umbilical Vein Endothelial Cells medicine Animals Humans Myocyte Myocytes Cardiac Myocardial infarction lcsh:Science Cells Cultured Multidisciplinary Chemistry lcsh:R Heart Hydrogels Blood flow 021001 nanoscience & nanotechnology medicine.disease Cell Hypoxia Microspheres Rats 3. Good health Disease Models Animal Treatment Outcome 030104 developmental biology cardiovascular system Cardiology lcsh:Q medicine.symptom 0210 nano-technology Myofibroblast |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-22 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Oxygen deficiency after myocardial infarction (MI) leads to massive cardiac cell death. Protection of cardiac cells and promotion of cardiac repair are key therapeutic goals. These goals may be achieved by re-introducing oxygen into the infarcted area. Yet current systemic oxygen delivery approaches cannot efficiently diffuse oxygen into the infarcted area that has extremely low blood flow. In this work, we developed a new oxygen delivery system that can be delivered specifically to the infarcted tissue, and continuously release oxygen to protect the cardiac cells. The system was based on a thermosensitive, injectable and fast gelation hydrogel, and oxygen releasing microspheres. The fast gelation hydrogel was used to increase microsphere retention in the heart tissue. The system was able to continuously release oxygen for 4 weeks. The released oxygen significantly increased survival of cardiac cells under the hypoxic condition (1% O2) mimicking that of the infarcted hearts. It also reduced myofibroblast formation under hypoxic condition (1% O2). After implanting into infarcted hearts for 4 weeks, the released oxygen significantly augmented cell survival, decreased macrophage density, reduced collagen deposition and myofibroblast density, and stimulated tissue angiogenesis, leading to a significant increase in cardiac function. |
| Databáze: | OpenAIRE |
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