The lens as a model for fibrotic disease
| Autor: | L. J. Dawes, Julie A. Eldred, I.M. Wormstone |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cell Communication
Disease Biology Models Biological General Biochemistry Genetics and Molecular Biology Extracellular matrix Transforming Growth Factor beta Fibrosis Lens Crystalline medicine Humans Cellular organization Inflammation Articles Transforming growth factor beta medicine.disease Extracellular Matrix Lens Diseases Cell Transdifferentiation Immunology biology.protein Lens disorder General Agricultural and Biological Sciences Neuroscience Myofibroblast |
| Zdroj: | Philosophical Transactions of the Royal Society B: Biological Sciences. 366:1301-1319 |
| ISSN: | 1471-2970 0962-8436 |
| DOI: | 10.1098/rstb.2010.0341 |
| Popis: | Fibrosis affects multiple organs and is associated with hyperproliferation, cell transdifferentiation, matrix modification and contraction. It is therefore essential to discover the key drivers of fibrotic events, which in turn will facilitate the development of appropriate therapeutic strategies. The lens is an elegant experimental model to study the processes that give rise to fibrosis. The molecular and cellular organization of the lens is well defined and consequently modifications associated with fibrosis can be clearly assessed. Moreover, the avascular and non-innervated properties of the lens allow effectivein vitrostudies to be employed that complementin vivosystems and relate to clinical data. Using the lens as a model for fibrosis has direct relevance to millions affected by lens disorders, but also serves as a valuable experimental tool to understand fibrosisper se. |
| Databáze: | OpenAIRE |
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