Impact of supervised exercise on skeletal muscle blood flow and vascular function measured with MRI in patients with peripheral artery disease

Autor:	Erin K. Englund, Michael C. Langham, Felix W. Wehrli, Molly J. Fanning, Zeeshan Khan, Kathryn H. Schmitz, Sarah J. Ratcliffe, Thomas F. Floyd, Emile R. Mohler
Rok vydání:	2022
Předmět:	Peripheral Arterial Disease Regional Blood Flow Physiology Physiology (medical) Exercise Test Humans Hyperemia Walking Intermittent Claudication Muscle Skeletal Cardiology and Cardiovascular Medicine Magnetic Resonance Imaging Exercise Therapy
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 323:H388-H396
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00633.2021
Popis:	Supervised exercise is a common therapeutic intervention for patients with peripheral artery disease (PAD), however, the mechanism underlying the improvement in claudication symptomatology is not completely understood. The hypothesis that exercise improves microvascular blood flow is herein tested via temporally resolved magnetic resonance imaging (MRI) measurement of blood flow and oxygenation dynamics during reactive hyperemia in the leg with the lower ankle-brachial index. One hundred and forty-eight subjects with PAD were prospectively assigned to standard medical care or 3 mo of supervised exercise therapy. Before and after the intervention period, subjects performed a graded treadmill walking test, and MRI data were collected with Perfusion, Intravascular Venous Oxygen saturation, and T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76f8ed3716d02300fc3f2212be086d https://doi.org/10.1152/ajpheart.00633.2021 Zobrazit plný text záznamu