Cationic and Biocompatible Polymer/Lipid Nanoparticles as Immunoadjuvants
| Autor: | Ana Maria Carmona-Ribeiro, Bianca de Carvalho Lins Fernandes Távora, Yunys Pérez-Betancourt, Péricles Marques Araujo, Daniele Rodrigues Pereira, Eliana L. Faquim-Mauro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
biocompatible polymer
Biocompatibility medicine.medical_treatment Pharmaceutical Science Emulsion polymerization cationic lipid delayed type hypersensitivity nanoparticles cytotoxicity Article CITOCINAS hybrid nanoparticles chemistry.chemical_compound Pharmacy and materia medica medicine Methyl methacrylate Chemistry Bilayer Cationic polymerization ovalbumin dynamic light scattering poly(methyl methacrylate) Poly(methyl methacrylate) Combinatorial chemistry RS1-441 cytokines profile visual_art visual_art.visual_art_medium dioctadecyl dimethyl ammonium bromide Hapten Adjuvant |
| Zdroj: | Pharmaceutics Volume 13 Issue 11 Pharmaceutics, Vol 13, Iss 1859, p 1859 (2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1999-4923 |
| Popis: | Nanostructures have been of paramount importance for developing immunoadjuvants. They must be cationic and non-cytotoxic, easily assembling with usually oppositely charged antigens such as proteins, haptens or nucleic acids for use in vaccines. We obtained optimal hybrid nanoparticles (NPs) from the biocompatible polymer poly(methyl methacrylate) (PMMA) and the cationic lipid dioctadecyl dimethyl ammonium bromide (DODAB) by emulsion polymerization of methyl methacrylate (MMA) in the presence of DODAB. NPs adsorbed ovalbumin (OVA) as a model antigen and we determined their adjuvant properties. Interestingly, they elicited high double immune responses of the cellular and humoral types overcoming the poor biocompatibility of DODAB-based adjuvants of the bilayer type. The results suggested that the novel adjuvant would be possibly of use in a variety of vaccines. |
| Databáze: | OpenAIRE |
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