Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects
| Autor: | Aralia Berenice Salgado-Bernabé, Ma. Elena Moreno-Godínez, Isela Parra-Rojas, Iris Paola Guzmán-Guzmán, Teresa Domínguez-Reyes, Lorenzo Salgado-Goytia, Natividad Castro-Alarcón, José Francisco Muñoz-Valle, Constanza C. Astudillo-López |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male Endocrinology Diabetes and Metabolism Clinical Biochemistry Gene Expression chemistry.chemical_compound Endocrinology Surveys and Questionnaires Fatty Acids Fasting LEPR Saturated fatty acid Receptors Leptin Female Apolipoprotein A-II Lipidology Adult Risk medicine.medical_specialty Adolescent Genotype Clinical nutrition APOA5 Diet High-Fat Polymorphism Single Nucleotide APOA2 Internal medicine Gene-diet interaction medicine Humans Obesity Apolipoproteins A Triglycerides Dyslipidemias Biochemistry medical business.industry Cholesterol Research Biochemistry (medical) Hypertriglyceridemia Cholesterol HDL Case-control study Cholesterol LDL medicine.disease Dietary Fats chemistry Dyslipidemia Apolipoprotein A-V Case-Control Studies business |
| Zdroj: | Lipids in Health and Disease |
| ISSN: | 1476-511X |
| Popis: | Background Diet is an important environmental factor that interacts with genes to modulate the likelihood of developing disorders in lipid metabolism and the relationship between diet and genes in the presence of other chronic diseases such as obesity. The objective of this study was to analyze the interaction of a high fat diet with the APOA2 (rs3813627 and rs5082), APOA5 (rs662799 and rs3135506) and LEPR (rs8179183 and rs1137101) polymorphisms and its relationship with obesity and dyslipidemia in young subjects. Methods The study included 200 young subjects aged 18 to 25 years (100 normal-weight and 100 obese subjects). Dietary fat intake was measured using the frequency food consumption questionnaire. Genotyping of polymorphisms was performed by PCR-RFLP. Results Individuals carrying the APOA5 56 G/G genotype with a high saturated fatty acid consumption (OR = 2.7, p = 0.006) and/or total fat (OR = 2.4, p = 0.018), associated with an increased risk of obesity. We also found that A/G + G/G genotypes of the 668 A/G polymorphism in the LEPR gene with an intake ≥12 g/d of saturated fatty acids, have 2.9 times higher risk of obesity (p = 0.002), 3.8 times higher risk of hypercholesterolemia (p = 0.002) and 2.4 times higher risk of hypertriglyceridemia (p = 0.02), than those with an intake |
| Databáze: | OpenAIRE |
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