Histone deacetylase inhibitors: emerging mechanisms of resistance
| Autor: | Agnes Basseville, Robert W. Robey, Arup R. Chakraborty, Zhirong Zhan, Julian C. Bahr, Susan E. Bates, Victoria Luchenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.drug_class
Pharmaceutical Science Biology Pharmacology Models Biological Article Romidepsin Food and drug administration chemistry.chemical_compound Panobinostat Neoplasms Drug Discovery medicine Humans Vorinostat Histone deacetylase inhibitor medicine.disease Lymphoma Clinical trial Histone Deacetylase Inhibitors chemistry Drug Resistance Neoplasm Cancer research Molecular Medicine Histone deacetylase medicine.drug |
| Popis: | The histone deacetylase inhibitors (HDIs) have shown promise in the treatment of a number of hematologic malignancies, leading to the approval of vorinostat and romidepsin for the treatment of cutaneous T-cell lymphoma and romidepsin for the treatment of peripheral T-cell lymphoma by the U. S. Food and Drug Administration. Despite these promising results, clinical trials with the HDIs in solid tumors have not met with success. Examining mechanisms of resistance to HDIs may lead to strategies that increase their therapeutic potential in solid tumors. However, relatively few examples of drug-selected cell lines exist, and mechanisms of resistance have not been studied in depth. Very few clinical translational studies have evaluated resistance mechanisms. In the current review, we summarize many of the purported mechanisms of action of the HDIs in clinical trials and examine some of the emerging resistance mechanisms. |
| Databáze: | OpenAIRE |
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