Timing the origin of eukaryotic cellular complexity with ancient duplications
| Autor: | Jolien J. E. van Hooff, Marina Marcet-Houben, Leny M. van Wijk, Toni Gabaldón, Berend Snel, Anne van Vlimmeren, Julian Vosseberg |
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| Přispěvatelé: | Theoretical Biology and Bioinformatics, Sub Bioinformatics, Barcelona Supercomputing Center |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC] Evolution Phylogeny--Molecular aspects Mitochondrion Biology 010603 evolutionary biology 01 natural sciences Genome Article 03 medical and health sciences 0302 clinical medicine Eukaryotic cell genetics Behavior and Systematics Molecular evolution Phylogenetics Phylogenomics Taverne Humans Prokaryotic cells Gene Ecology Evolution Behavior and Systematics Phylogeny 030304 developmental biology 0303 health sciences Phylogenetic tree Endosymbiosis Ecology Evolutionary theory Eukaryota Archaea Biological Evolution Genòmica Order (biology) Eukaryotic Cells Evolutionary biology 030217 neurology & neurosurgery |
| Zdroj: | Nature ecology & evolution UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Nature Ecology and Evolution, 5(1), 92. Nature Publishing Group |
| ISSN: | 2397-334X |
| Popis: | Eukaryogenesis is one of the most enigmatic evolutionary transitions, during which simple prokaryotic cells gave rise to complex eukaryotic cells. While evolutionary intermediates are lacking, gene duplications provide information on the order of events by which eukaryotes originated. Here we use a phylogenomics approach to reconstruct successive steps during eukaryogenesis. We find that gene duplications roughly doubled the proto-eukaryotic gene repertoire, with families inherited from the Asgard archaea-related host being duplicated most. By relatively timing events using phylogenetic distances, we inferred that duplications in cytoskeletal and membrane-trafficking families were among the earliest events, whereas most other families expanded predominantly after mitochondrial endosymbiosis. Altogether, we infer that the host that engulfed the proto-mitochondrion had some eukaryote-like complexity, which drastically increased upon mitochondrial acquisition. This scenario bridges the signs of complexity observed in Asgard archaeal genomes to the proposed role of mitochondria in triggering eukaryogenesis. We thank K. S. Marakova and E. V. Koonin for sharing their KOG-to-COG protein clusters with us. We are grateful to T. J. P. van Dam, E. S. Deutekom and G. J. P. L. Kops for useful advice and discussions. This work is part of the research programme VICI with project number 016.160.638, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). T.G. acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00 and from the European Union’s Horizon 2020 research and innovation programme under grant agreement ERC-2016-724173. |
| Databáze: | OpenAIRE |
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