Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital
| Autor: | Konstantina Chrysou, Nikolaos Sypsas, Olympia Zarkotou, Katina Themeli-Digalaki, Athanasios Tsakris, Vasiliki Mamali, Sofia Kalofolia, Spyros Pournaras, Panagiota Papagiannakopoulou, Georgios Chrysos |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Klebsiella pneumoniae medicine.drug_class Antibiotics Bed days Tigecycline medicine.disease_cause Tertiary Care Centers Antimicrobial Stewardship Medical microbiology Internal medicine Drug Resistance Bacterial Medicine Antimicrobial stewardship Humans Prospective Studies biology Bacteria Greece business.industry Pseudomonas aeruginosa General Medicine Bacterial Infections biology.organism_classification Anti-Bacterial Agents Infectious Diseases Colistin business medicine.drug |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 41(1) |
| ISSN: | 1435-4373 |
| Popis: | This study aimed to investigate the effects of a 4-year antibiotic stewardship program (ASP) in a tertiary hospital. We monitored data for 2015 (pre-intervention) and 2016-2019 (post-intervention) about antibiotic consumption (DDD/100 bed days), Clostridioides difficile infections (CDIs), resistance rates, length of stay (LOS), and annual antibiotic costs. Significant reductions were observed for total antibiotics/colistin/carbapenems/quinolones/tigecycline consumption and resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and vancomycin-resistant enterococci. Considerable reductions occurred for LOS (4.18 [2015]/3.0 [2019] days), CDIs (1.47 [2015]/0.86 [2019] per 1000 patients), antibiotic cost/patient (39.45€ [2015]/23.69€ [2019]). The ASP was successful in reducing antibiotic consumption, antibiotic costs, length of hospital stay, and CDIs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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