Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures
| Autor: | Wakana Goto, Hideaki Hara, Masaki Ichikawa, Makoto Araie, Etsuko Tanaka |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Bunazosin Glutamic Acid Neuroprotection Retina chemistry.chemical_compound Pregnancy Internal medicine medicine Animals Rats Wistar Molecular Biology Cells Cultured Cell Death Dose-Response Relationship Drug General Neuroscience Glutamate receptor Neurotoxicity Antagonist Brain Retinal medicine.disease Rats Endocrinology Mechanism of action chemistry Quinazolines Female Neurology (clinical) medicine.symptom Veratridine Protein Binding Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1003:130-137 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2003.12.030 |
| Popis: | To study neuroprotective effects of bunazosin hydrochloride which is an alpha(1)-adrenoceptor antagonist used as an ocular hypotensive drug compared to other alpha(1)-adrenoceptor antagonists, and its mechanism of action. We evaluated the neuroprotective effects of bunazosin hydrochloride or seven other alpha(1)-adrenoceptor antagonists against glutamate-induced cell death in rat primary retinal cultures. We also evaluated the binding inhibition of bunazosin hydrochloride for 24 different receptors/channels and its effects on the Na(+) influx into cells induced by veratridine or glutamate. Bunazosin hydrochloride significantly inhibited glutamate-induced cell death at concentrations of 1 and 10 microM. Cells were also protected when treated with some alpha(1)-adrenoceptor antagonists, but not by the others. Bunazosin hydrochloride showed a high inhibition for Na(+) channels and inhibited the Na(+) influx induced by veratridine or glutamate. These findings indicate that in retinal cultures bunazosin hydrochloride has a neuroprotective effect against glutamate-induced cell death and that the inhibition of Na(+) channels by bunazosin hydrochloride may be partly responsible for this effect. |
| Databáze: | OpenAIRE |
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