The First-Generation Drug-Eluting Stents and Coronary Endothelial Dysfunction
| Autor: | Dongming Hou, Jack P. Chen, Nicolas Chronos, Xinhua Yin, Jinsheng Li, Lakshmana K. Pendyala |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Drug
medicine.medical_specialty Time Factors Paclitaxel Endothelium media_common.quotation_subject medicine.medical_treatment Coronary Artery Disease Coronary Angiography Prosthesis Design Risk Assessment vasomotor dysfunction Risk Factors Internal medicine Angioplasty endothelial medicine Animals Humans Angioplasty Balloon Coronary Endothelial dysfunction Pathological media_common Sirolimus business.industry Vasomotor dysfunction drug-eluting stents Cardiovascular Agents medicine.disease Coronary Vessels First generation Treatment Outcome medicine.anatomical_structure Cardiology Endothelium Vascular Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | JACC: Cardiovascular Interventions. 2:1169-1177 |
| ISSN: | 1936-8798 |
| DOI: | 10.1016/j.jcin.2009.10.004 |
| Popis: | Recently, a growing body of clinical data has shown that the first generation of drug-eluting stents (1st-gen DES) implantation could elicit coronary conduit artery vasomotor dysfunction at nonstented reference segments as late as 12 months after implantation compared with that seen with bare-metal stents. The mechanism of this phenomenon is still not fully understood. Pathological studies have implicated delayed arterial healing and poor re-endothelialization after the 1st-gen DES implantation. Given the vast use of DES globally, a thorough understanding of the early and long-term safety of these devices is paramount. Therefore, this article systematically reviews the current clinical, pathophysiological, and histopathological available data regarding 1st-gen DES-associated vascular endothelial dysfunction. Meanwhile, we will also review the newer generation of DES and emerging endothelial-friendly technology. |
| Databáze: | OpenAIRE |
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