Role of Bacterial Virulence Factors and Host Factors in the Outcome of Escherichia coli Bacteraemia
| Autor: | H. Connell, T. A. M. Hekker, D. M. Maclaren, A. M. Simoons-Smit, A. B. J. Groeneveld, P. de Man |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Microbiology (medical) Blood Bactericidal Activity medicine.medical_specialty Fimbria Virulence Bacteremia Biology medicine.disease_cause Virulence factor Microbiology Hemolysin Proteins Medical microbiology Antigen Risk Factors Escherichia coli medicine Humans Escherichia coli Infections Aged Univariate analysis Hemolysin General Medicine Infectious Diseases Multivariate Analysis Immunology Regression Analysis Female |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 19:312-316 |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | In a study of the role of virulence factors in the outcome of Escherichia coli bacteraemia, blood isolates from 30 hospitalised patients were characterised with regard to O and K antigens, P and type 1 fimbriae, haemolysin production, cytonecrotising factor 1 production, serum resistance, ability to activate neutrophils and resistance to killing. Patients were analysed to identify host factors contributing to morbidity and mortality. In univariate analyses the presence of a K antigen, type 1 fimbriae, absence of haemolysin production, serum resistance and resistance to killing were associated with morbidity and mortality. In multivariate analyses only the absence of haemolysin production was associated with morbidity and mortality, after taking host factors into account. These preliminary findings suggest that host factors override bacterial virulence factors in determining the course of Escherichia coli bacteraemia. The negative association between haemolysin production and clinical deterioration during Escherichia coli bacteraemia might indicate predominance of less virulent strains in patients with other risk factors for morbidity and mortality or inactivation of neutrophil products needed for host defence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink