Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery
| Autor: | Maurizio Ferratini, Paolo Castiglioni, Vittorio Racca, Maria Gaetana Calvo, Vittorino Ripamonti |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Heart disease Anemia Angiotensin-Converting Enzyme Inhibitors Critical Care and Intensive Care Medicine Gastroenterology Hemoglobins Enalapril Internal medicine medicine Humans Erythropoiesis Postoperative Period Cardiac Surgical Procedures Ejection fraction biology business.industry Extracorporeal circulation Stroke Volume Angiotensin-converting enzyme Middle Aged medicine.disease Endocrinology Enalapril Maleate ACE inhibitor biology.protein Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 130:79-84 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.130.1.79 |
| Popis: | Angiotensin-converting enzyme (ACE) inhibitors, which are frequently administered in patients with heart disease, have a known inhibitory effect on erythropoiesis. The aim of this study was to detect whether early ACE inhibitor administration slows recovery from anemia following recent cardiac surgery.Forty male patients with anemia (hemoglobin12 g/dL) an average of 9 days after cardiac surgery were randomized to receive enalapril (ACE inhibitor group) or not. All of the patients received ferrous sulfate, 525 mg, in addition to standard therapy. Patients with anemia due to other causes were excluded. Blood samples were obtained at baseline, and after 8 days, 16 days, and 60 days. A 6-min walking test and echocardioscan were performed at baseline, and after 16 days and 60 days of treatment, and a chest radiograph was obtained at baseline and after 60 days. The ACE inhibitor group showed a statistically significant lower increase in hemoglobin and RBC values. The peak between-group differences of 1 g/dL of hemoglobin (p = 0.012) and 444 RBCs per milliliter (p = 0.017) were observed on day 16.Early enalapril maleate administration in anemic patients after heart surgery significantly inhibits erythropoiesis. This unfavorable effect on anemia should be considered when prescribing ACE inhibitors for such patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|