Immunological cross-reactivities of various anthracycline antibiotics against aclacinomycin a antisera
| Autor: | Tomoyuki Ishikura, Yasue Matsuzawa, Toshio Kiyosaki, Tomio Takeuchi, Hamao Umezawa, Akihiro Yoshimoto |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Pharmacology Antiserum Antibiotics Antineoplastic Naphthacenes biology Stereochemistry Immune Sera Serum albumin Disaccharide Radioimmunoassay Cross Reactions Hydroxylation Structure-Activity Relationship chemistry.chemical_compound Aglycone chemistry Biochemistry biology.protein Animals Moiety Rabbits Aclarubicin Conjugate |
| Zdroj: | Journal of Pharmacobio-Dynamics. 5:886-892 |
| ISSN: | 1881-1353 0386-846X |
| Popis: | Aclacinomycin A (ACM) antisera were abtained from the rabbits immunized with 4'''-deoxo-4'''-(R)-amino-ACM-or N, N-didemethyl-ACM-bovine serum albumin conjugate, and their immunoreactivites were tested with ACM-related anthracyclines. It was found that the binding ability with the ACM antisera was markedly decreased by the following structural changes in ACM : N, N-didementhylation of the rhodosamine moiety ; 6-O-or 4-O-methylation ; removal of the methoxycarbonyl group at C-10 ; hydroxylation at C-1, C-2 or C-11. It was less affected by some alterations in a side chain at C-9 or by deglycosidation of the terminal mono or disaccharide. The binding of the aglycone (aklavinone) was very weak. |
| Databáze: | OpenAIRE |
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