Humoral immune function in pediatric patients treated with autologous bone marrow transplantation for B cell non-Hodgkin's lymphoma. The influence of ex vivo marrow decontamination with anti-Y 29/55 monoclonal antibody and complement
| Autor: | H. P. Wagner, L Matter, Andreas Hirt, G. P. Brun del Re, C. Baumgartner, H. K. Forster, Andreas Morell, Doran Je, U. Bucher |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Poliomyelitis vaccine
Pathology medicine.medical_specialty biology business.industry Immunology Cell Biology Hematology Total body irradiation medicine.disease Biochemistry Non-Hodgkin's lymphoma Transplantation medicine.anatomical_structure Immune system medicine biology.protein Bone marrow Antibody business B cell |
| Zdroj: | Blood. 71:1211-1217 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v71.5.1211.bloodjournal7151211 |
| Popis: | Elimination of neoplastic B cell populations from autologous bone marrow grafts also removes normal B lymphocytes. This is potentially hazardous for the reconstitution of the immune system in patients undergoing high-dose chemotherapy and total body irradiation followed by autologous marrow rescue. Five pediatric patients with B cell non- Hodgkin's lymphoma in first remission undergoing such a regimen were studied. They received bone marrow pretreated with anti-Y 29/55 monoclonal antibody and complement. B and T lymphocyte subpopulations reached normal levels within 6 months after autologous bone marrow transplantation (ABMT), and serum immunoglobulin levels became normal within 4 to 9 months. Vaccination with diphtheria and tetanus toxoid, trivalent poliomyelitis vaccine of the Salk type, and pneumococcal capsular antigens (38 to 54 months after transplantation) gave rise to specific antibody production. ABO isoagglutinins could be demonstrated in all patients. The response pattern was similar to that of patients who received unmanipulated autologous bone marrow. It is concluded that ex vivo anti-Y 29/55 depletion of the marrow graft does not induce relevant disturbances of humoral immune functions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|