Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens
| Autor: | Jr Jf John, KE Price, WF McNeill, PA Kresel |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
DNA
Bacterial Serotype Substrate Specificity Microbiology Plasmid Acetyltransferases Kanamycin Escherichia coli medicine Tobramycin Pharmacology (medical) Amikacin Serratia marcescens Pharmacology biology Aminoglycoside Drug Resistance Microbial Chromosomes Bacterial biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Virology Anti-Bacterial Agents carbohydrates (lipids) Aminoglycosides Infectious Diseases Conjugation Genetic Gentamicin Plasmids Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 21:587-591 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | We studied 21 strains of amikacin-resistant Serratia marcescens from three different U.S. cities, Twenty of the 21 strains contained conjugative R plasmids mediating gentamicin and tobramycin resistance. Amikacin-resistant S. marcescens from two cities predominated in protracted outbreaks. Conversely, the amikacin-resistant Charleston strain (serotype 02/03:nonmotile) was isolated from only four patients during an outbreak of gentamicin- and tobramycin resistant, amikacin-susceptible S. marcescens (serotype O19:O17). Five different representative amikacin-resistant S. marcescens, each containing a single conjugative plasmid, elaborated a nontransferable aminoglycoside (6')-N-acetyltransferase [AAC(6')] with similar substrate profiles in addition to other transferable aminoglycoside-modifying enzymes. One amikacin-resistant S. marcescens cured of its plasmid and another naturally occurring plasmid-free amikacin-resistant S. marcescens elaborated only AAC(6')-1. These data support the concept of a chromosomal locus in S. marcescens for AAC(6')-1 which commonly coexists with plasmid-mediated genes for aminoglycoside-modifying enzymes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|