Clinical and Bacteriologic Impact of Rifabutin Prophylaxis for Mycobacterium avium Complex Infection in Patients with Human Immunodeficiency Virus Infection
| Autor: | Anne Buré-Rossier, Willy Rozenbaum, Yasmine Gholizadeh, Pierre-Marie Girard, Marie-Gisèle Lebrette, Caroline Maslo |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Rifabutin medicine.drug_class Opportunistic infection Antibiotics Mycobacterium avium-intracellulare infection Gastroenterology Mycobacterium Internal medicine medicine Humans Prospective Studies Sida Adverse effect Mycobacterium avium-intracellulare Infection AIDS-Related Opportunistic Infections biology business.industry Mycobacterium avium Complex medicine.disease biology.organism_classification Anti-Bacterial Agents Infectious Diseases Bacteremia Immunology Chemoprophylaxis Female business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 24:344-349 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | We conducted a prospective observational study to determine the feasibility and impact of rifabutin prophylaxis (300 mg daily) for human immunodeficiency virus-infected patients whose CD4 cell counts were100/mm3. Three hundred seventy-one patients (65.2% of all patients with CD4 cell counts of100/mm3 [mean +/- SD, 30 +/- 25/mm3]) received rifabutin prophylaxis for a mean duration +/- SD of 35.5 +/- 34.2 weeks; 198 patients (mean CD4 cell count +/- SD, 51.6 +/- 32/mm3) did not receive prophylaxis. Rifabutin prophylaxis for 8.4% of patients was interrupted because of adverse events. Mycobacterium avium complex (MAC) bacteremia developed in 17 (4.6%) of 371 patients receiving rifabutin prophylaxis and in 22 (11.1%) of 198 patients not receiving rifabutin prophylaxis. The mean CD4 cell count +/- SD at the diagnosis of MAC bacteremia was lower in patients receiving prophylaxis than in those not receiving prophylaxis (11.5 +/- 6.8/mm3 vs. 34.7 +/- 36/mm3, respectively; P.01). MICs for MAC strains isolated from patients receiving prophylaxis were less than or equal to those for strains isolated from patients not receiving prophylaxis. |
| Databáze: | OpenAIRE |
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