Evaluation of heavy metals in cosmetic products and their health risk assessment
| Autor: | Munir H. Shah, Arshad Mehmood Abbasi, Hamna Arshad, Moniba Zahid Mehmood |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
media_common.quotation_subject
Pharmaceutical Science Cosmetics 010501 environmental sciences MoS 01 natural sciences Article HI Toxicology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine HQ Pakistan Human safety 0105 earth and related environmental sciences media_common Pharmacology Health risk assessment lcsh:RM1-950 Heavy metals Hazard index Contamination Hazard quotient Heavy metal lcsh:Therapeutics. Pharmacology LCR Health risk Margin of safety Environmental science |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 28, Iss 7, Pp 779-790 (2020) Saudi Pharmaceutical Journal : SPJ |
| ISSN: | 1319-0164 |
| DOI: | 10.1016/j.jsps.2020.05.006 |
| Popis: | Heavy metals’ contamination in cosmetic products is a serious threat. Present study was conducted to evaluate the concentrations of heavy metals (HMs) in various brands of cosmetic products with special emphasis on their health risk assessment. Five heavy metals including Cd, Cr, Fe, Ni and Pb were quantified in different brands of lotions, foundations, whitening creams, lipsticks, hair dyes and sunblock creams using atomic absorption spectrometry. Risk to the consumer’s health was determined using systemic exposure dosage (SED), margin of safety (MoS), hazard quotient (HQ), hazard index (HI) and lifetime cancer risk (LCR). On comparative basis, different brands of sunblock creams depicted highest concentration of Ni, Pb and Cr (7.99 ± 0.36, 6.37 ± 0.05 and 0.43 ± 0.01 mg/kg, respectively), whereas lipsticks had elevated levels of Fe at 12.0 ± 1.8 mg/kg, and Cd was maximum in lotions (0.26 ± 0.02 mg/kg). Multivariate analysis revealed strong associations among Cr, Ni and Pb, while Cd and Fe showed disparity in distribution and sources of contamination. MoS, HQ and HI values were within the permissible limit apart from for lotions and sunblock creams, while LCR value was higher than the permissible limit in all cosmetic products except lipsticks. Regular use of these products can cause serious threat to human health, particularly skin cancer on long time exposure. Therefore, continuous monitoring of cosmetic products, particularly with reference to HMs adulteration should be adopted to ensure the human safety and security. |
| Databáze: | OpenAIRE |
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