Effect of Right Posterior Bile Duct Anatomy on Biliary Complications in Patients Undergoing Right Lobe Living Donor Liver Transplant
| Autor: | Nadire Dinc, Tugan Tezcaner, Mahir Kirnap, Mehmet Haberal, Feza Karakayali, Mehmet Coskun, Gokhan Moray |
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| Rok vydání: | 2019 |
| Předmět: |
Cholangiopancreatography
Magnetic Resonance Anastomotic Leak Bile Duct Diseases Anastomosis Risk Assessment Risk Factors Living Donors Humans Medicine In patient Risk factor Retrospective Studies Transplantation Receiver operating characteristic Portal Vein business.industry Bile duct Anatomy Odds ratio Confidence interval Lobe Liver Transplantation Treatment Outcome medicine.anatomical_structure Bile Ducts business Cholangiography |
| Zdroj: | Experimental and Clinical Transplantation. :759-767 |
| ISSN: | 2146-8427 1304-0855 |
| DOI: | 10.6002/ect.2016.0200 |
| Popis: | OBJECTIVES Our aim was to evaluate the influence of the localization of right posterior bile duct anatomy relative to portal vein of the donors on posttransplant bile duct complications. MATERIALS AND METHODS We retrospectively investigated 141 patients who had undergone living donor liver transplant using right hemiliver grafts. The patients were classified based on the pattern of the right posterior bile duct and divided into infraportal and supraportal types. Clinical donor and recipient risk factors and surgical outcomes were compared for their relationship with biliary complications using logistic regression analyses. RESULTS The 2 groups were similar according to demographic and clinical features. The biliary complication rate was 23.7% (9/38) in the infraportal group and 47.4% (37/78) in the supraportal group (P = .014). An analysis of risk factors for the development of anastomotic bile leak using logistic regression showed that a supraportal right posterior bile duct anatomy was a statistically significant positive predictor, with odds ratio of 18.905 (P = .012; confidence interval, 1.922-185.967). The distance of the right posterior bile duct from confluence was significantly lower in patients with biliary complications than in those without (mean of 7.66 vs 0.40 mm; P = .044). According to receiver operating characteristic analyses, the cut-off point for the length of right bile duct to right posterior bile duct from the hepatic confluence was 9.5 mm regarding presence of complications. CONCLUSIONS Factors influencing bile duct anastomosis leakage were supraportal-type donor bile duct anatomy and length of the right main bile duct from biliary confluence. Hepatic arterial complications were similarly a risk factor for biliary strictures. Because of the multiple factors leading to complications in living donor liver transplant, it is challenging to group these patients by operative risk; however, establishing risk models may facilitate the prediction of complications. |
| Databáze: | OpenAIRE |
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