Chemical Constituents from the Whole Plant ofGaultheria itoanaHayata
| Autor: | Rong-Jyh Lin, Chung Yi Chen, His-Chou Hung, Jin-Cherng Huang, Ming-Jen Cheng, Yi-Hung Wu, Wen-Li Lo |
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| Rok vydání: | 2009 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Lung Neoplasms Magnetic Resonance Spectroscopy Chemical structure Palmitic Acid Stigmasterol Parabens Bioengineering Biochemistry Cinnamic acid Palmitic acid chemistry.chemical_compound Cell Line Tumor Vanillic acid Humans Organic chemistry Medicinal plants Molecular Biology Vanillic Acid Chromatography Molecular Structure biology Plant Extracts Methanol General Chemistry General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Sitosterols chemistry Cinnamates Ericaceae Molecular Medicine Stearic acid Diterpenes Gaultheria Stearic Acids |
| Zdroj: | Chemistry & Biodiversity. 6:1737-1743 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.200800270 |
| Popis: | Two new diterpenoids, 14,18-dihydroxyabieta-8,11,13-trien-7-one (1) and 13-acetyl-14,18-dihydroxy-podocarpa-8,11,13-triene (2), together with eight known compounds, i.e., gaultheric acid (3), vanillic acid (4), 4-hydroxybenzoic acid (5), cinnamic acid (6), stearic acid (7), palmitic acid (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the MeOH extract of the whole plant of Gaultheria itoana Hayata (Ericaceae). The structures of the new constituents were elucidated by spectroscopic methods (UV, IR, and 1D- and 2D-NMR) and by mass spectrometry (HR-ESI-MS). Among them, 1 and 2 were demonstrated to exhibit significant cytotoxic activity against the LNCaP cell line. |
| Databáze: | OpenAIRE |
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