Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report
| Autor: | Filiz Ekici, Mehmet Emre Ari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Case Report Propafenone 030204 cardiovascular system & hematology Ventricular tachycardia Sudden cardiac death 03 medical and health sciences Electrocardiography 0302 clinical medicine children Internal medicine medicine Humans 030212 general & internal medicine propafenone cardiovascular diseases Brugada syndrome Brugada Syndrome Phenocopy medicine.diagnostic_test business.industry Brugada phenocopy lcsh:R General Medicine medicine.disease Brugada-like electrocardiography pattern Ajmaline Phenotype Ventricular fibrillation Cardiology business Brugada-like electrocardiography pattern propafenone children Brugada phenocopy medicine.drug |
| Zdroj: | Volume: 34, Issue: 5 473-475 Balkan Medical Journal Balkan Medical Journal, Vol 34, Iss 5, Pp 473-475 (2017) |
| ISSN: | 2146-3123 |
| Popis: | 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. Background: Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propafenone intoxication and its treatment. Case Report: A 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone (Rythmol, Abbott, Chicago, IL, USA) for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. After bicarbonate infusion for 4 hours, haemodynamic and neurologic findings were recovered, and all electrocardiography abnormalities disappeared. The Brugada-like electrocardiography pattern was not recognized in her surface and 24-hour Holter electrocardiography at follow-up. Ajmaline challenge test was negative 2 weeks later. Conclusion: Absence of symptoms and documented ventricular tachycardia, negative challenge test, and a negative family history demonstrated that the Brugada phenocopy was a transient finding in this case and related to propafenone intoxication. |
| Databáze: | OpenAIRE |
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