Toxic epidermal necrolysis related to AP (pemetrexed plus cisplatin) and gefitinib combination therapy in a patient with metastatic non-small cell lung cancer
| Autor: | Zhao Wang, Tao Qin, Shu Xiang Ma, Li Kun Chen, Xiao Xiao Dinglin, Yin Duo Zeng, Xue Hou, Ji Jie Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Guanine Lung Neoplasms medicine.drug_class medicine.medical_treatment gefitinib drug-related bullous disease Pemetrexed Pharmacology Tyrosine-kinase inhibitor Gefitinib Glutamates Carcinoma Non-Small-Cell Lung Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Epidermal growth factor receptor Neoplasm Metastasis Lung cancer non-small cell lung cancer Chemotherapy biology business.industry Toxic epidermal necrolysis medicine.disease Rash Case Research respiratory tract diseases Stevens-Johnson Syndrome Quinazolines biology.protein Female Cisplatin medicine.symptom business medicine.drug |
| Zdroj: | Chinese Journal of Cancer |
| ISSN: | 1944-446X 1000-467X |
| DOI: | 10.5732/cjc.014.10151 |
| Popis: | Toxic epidermal necrolysis (TEN) is a rare acute life-threatening mucocutaneous disorder that is mostly drug-related (80%-95%). It is clinically characterized as a widespread sloughing of the skin and mucosa. AP regimen (pemetrexed plus cisplatin) has been the preferred first-line chemotherapy for metastatic non-squamous non-small cell lung cancer (NSCLC). Gefitinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), has already been recommended as a first-line treatment in EGFR-mutant metastatic NSCLC. We report rare presentation of TEN involving adverse effects of AP and gefitinib combination treatment in a 42-year-old woman diagnosed with metastatic NSCLC harboring an EGFR mutation. On the 21st day after administration of the first cycle of AP regimen and the 8th day after the initiation of gefitinib treatment, she developed an acne-like rash, oral ulcer, and conjunctivitis, which later became blisters and ultimately denuded. The characteristic clinical courses were decisive for the diagnosis of TEN. Treatment with systemic steroids and immunoglobulin as well as supportive treatment led to an improvement of her general condition and a remarkable recovery. |
| Databáze: | OpenAIRE |
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