| Autor: |
Bárbara M, Schultz, Felipe, Melo-González, Luisa F, Duarte, Nicolás Ms, Gálvez, Gaspar A, Pacheco, Jorge A, Soto, Roslye V, Berríos-Rojas, Liliana A, González, Daniela, Moreno-Tapia, Daniela, Rivera-Pérez, Mariana, Ríos, Yaneisi, Vázquez, Guillermo, Hoppe-Elsholz, Omar P, Vallejos, Carolina, Iturriaga, Marcela, Urzua, María S, Navarrete, Álvaro, Rojas, Rodrigo, Fasce, Jorge, Fernández, Judith, Mora, Eugenio, Ramírez, Aracelly, Gaete-Argel, Mónica, Acevedo, Fernando, Valiente-Echeverría, Ricardo, Soto-Rifo, Daniela, Weiskopf, Alba, Grifoni, Alessandro, Sette, Gang, Zeng, Weining, Meng, José V, González-Aramundiz, Pablo A, González, Katia, Abarca, Alexis M, Kalergis, Susan M, Bueno |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
medRxiv : the preprint server for health sciences. |
| Popis: |
BackgroundCoronaVac®is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization. Previous studies reported increased levels of neutralizing antibodies and specific T cells two- and four-weeks after two doses of CoronaVac®, but the levels of neutralizing antibodies are reduced at six to eight months after two doses. Here we report the effect of a booster dose of CoronaVac®on the anti-SARS-CoV-2 immune response generated against variants of concern (VOC) Delta and Omicron in adults participating in a phase 3 clinical trial in Chile.MethodsVolunteers immunized with two doses of CoronaVac®in a four-week interval received a booster dose of the same vaccine between twenty-four and thirty weeks after the 2nd dose. Four weeks after the booster dose, neutralizing antibodies and T cell responses were measured. Neutralization capacities and T cell activation against VOC Delta and Omicron were detected at four weeks after the booster dose.FindingsWe observed a significant increase in neutralizing antibodies at four weeks after the booster dose. We also observed an increase in CD4+T cells numbers over time, reaching a peak at four weeks after the booster dose. Furthermore, neutralizing antibodies and SARS-CoV-2 specific T cells induced by the booster showed activity against VOC Delta and Omicron.InterpretationOur results show that a booster dose of CoronaVac®increases the anti-SARS-CoV-2 humoral and cellular immune responses in adults. Immunity induced by a booster dose of CoronaVac®is active against VOC, suggesting an effective protection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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