PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4/MyD88/NFκB pathway

Autor:	Biao Xu, Haiyun Liu, Bingjian Wang, Xiwen Zhang, Tingting Hu, Jun Xie, Peibing Ge, Yanchun Zhang, Jin Geng
Rok vydání:	2019
Předmět:	CD36 Antigens Health Toxicology and Mutagenesis Myocytes Smooth Muscle 0211 other engineering and technologies Vulnerability 02 engineering and technology 010501 environmental sciences complex mixtures 01 natural sciences Mice Apolipoproteins E Air Pollution Animals Medicine cardiovascular diseases Myocardial infarction Particle Size 0105 earth and related environmental sciences Foam cell 021110 strategic defence & security studies business.industry Macrophages NF-kappa B Public Health Environmental and Occupational Health General Medicine Atherosclerosis medicine.disease Pollution Plaque Atherosclerotic Toll-Like Receptor 4 Clinical evidence Myeloid Differentiation Factor 88 Cancer research TLR4 Particulate Matter business Foam Cells
Zdroj:	Ecotoxicology and Environmental Safety. 176:76-84
ISSN:	0147-6513
Popis:	Clinical evidence has shown an elevated myocardial infarction (MI) risk after PM2.5 (particulate matter 2.5 μm) exposure. Incident MI may result from rupture of vulnerable plaques. To test whether PM2.5 could promote plaque vulnerability, we exposed PM2.5 to apoe
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5c63a91366c3ced2ad185df85b92b3 https://doi.org/10.1016/j.ecoenv.2019.03.068 Zobrazit plný text záznamu Full Text from ScienceDirect