On the Polymorphism of Griseofulvin: Identification of Two Additional Polymorphs

Autor: Aurélien Mahieu, Mark D. Eddleston, William Jones, Jean-François willart, Marc Descamps, Emeline Dudognon, Florence Danede
Rok vydání: 2013
Předmět:
Zdroj: Journal of Pharmaceutical Sciences. 102:462-468
ISSN: 0022-3549
DOI: 10.1002/jps.23349
Popis: In this paper, we present an investigation of the polymorphism of griseofulvin. In addition to the only reported crystalline form (form I), two new polymorphic forms (II and III) have been identified and characterized by differential scanning calorimetry and powder X-ray diffraction. Reasons why these two polymorphs were isolated during the present study, but not detected during the numerous previous studies on this drug, are also discussed.
Databáze: OpenAIRE