Down-regulation of FHIT inhibits apoptosis of colorectal cancer: Mechanism and clinical implication
| Autor: | Jie Cao, Weibiao Tang, Wanqing Xiao, Hui Wang, Jie Xie, Xiwen Chen, Hong Du, Yuyuan Li, Wanglin Li |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Tumor suppressor gene Survivin Gene Expression Apoptosis Colorectal adenoma medicine.disease_cause Inhibitor of Apoptosis Proteins FHIT medicine Humans Genes Tumor Suppressor neoplasms Aged bcl-2-Associated X Protein Aged 80 and over Tissue microarray business.industry Middle Aged medicine.disease Survival Analysis Candidate Tumor Suppressor Gene digestive system diseases Acid Anhydride Hydrolases Genes bcl-2 Neoplasm Proteins Oncology Case-Control Studies Mutation Cancer research Adenocarcinoma Female Surgery Colorectal Neoplasms Carcinogenesis business Microtubule-Associated Proteins |
| Zdroj: | Surgical Oncology. 15:223-233 |
| ISSN: | 0960-7404 |
| DOI: | 10.1016/j.suronc.2007.01.006 |
| Popis: | Fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in carcinogenesis of many human tissues, including digestive tract tissues. However, the expression and role of FHIT in the initiation and the development of the colorectal cancer (CRC) are poorly understood. In our present study, we have demonstrated that the FHIT gene exhibits significantly decreased expression in human CRC compared to colorectal adenoma and normal colorectal tissue by tissue microarray (TMA). The positive of FHIT gene expression in normal colorectal tissue, adenoma and adenocarcinoma were 93.75%, 68.75% and 46.25%, respectively. We showed that decreased FHIT expression was significantly correlated with the progression of colorectal carcinoma (P |
| Databáze: | OpenAIRE |
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