Simulated urban carbon monoxide air pollution exacerbates rat heart ischemia-reperfusion injury
| Autor: | Stéphane Tanguy, S. Richard, F. Boucher, Julien Boissiere, Philippe Obert, O. Cazorla, Félicie Lopez-Lauri, Cyril Reboul, Grégory Meyer, Charlotte Farah, Sandrine Gayrard, L. André |
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| Přispěvatelé: | Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Section of Mineralogy and Petrography, Royal Museum for Central Africa [Tervuren] (RMCA), Physiopathologie des adaptations cardiovasculaires à l'Exercice, Avignon Université (AU), Physiopathologie cardiovasculaire, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée (TIMC-IMAG-PRETA), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Physiology MESH: Air Pollutants Air pollution MESH: Myocytes Cardiac Environmental pollution 030204 cardiovascular system & hematology medicine.disease_cause Antioxidants chemistry.chemical_compound 0302 clinical medicine 11. Sustainability Medicine MESH: Coronary Vessels Myocytes Cardiac MESH: Animals Myocardial infarction health care economics and organizations MESH: Superoxide Dismutase Air Pollutants Carbon Monoxide 0303 health sciences MESH: Oxidative Stress MESH: Sarcomeres Coronary Vessels MESH: Myocardial Reperfusion Injury 3. Good health MESH: Arrhythmias Cardiac Anesthesia MESH: Calcium Circulatory system Cardiology and Cardiovascular Medicine MESH: Carbon Monoxide Sarcomeres MESH: Air Pollution MESH: L-Lactate Dehydrogenase MESH: Myocardium MESH: Rats Heart Ventricles education Ischemia Myocardial Reperfusion Injury 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Air Pollution Physiology (medical) Animals Rats Wistar 030304 developmental biology Glutathione Peroxidase L-Lactate Dehydrogenase Superoxide Dismutase business.industry Myocardium MESH: Antioxidants Arrhythmias Cardiac Rat heart MESH: Rats Wistar medicine.disease MESH: Male Rats Oxidative Stress chemistry 13. Climate action MESH: Glutathione Peroxidase Calcium [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Heart Ventricles business Reperfusion injury Carbon monoxide |
| Zdroj: | AJP-Heart and Circulatory Physiology AJP-Heart and Circulatory Physiology, American Physiological Society, 2010, 298 (5), pp.H1445-53. ⟨10.1152/ajpheart.01194.2009⟩ AJP-Heart and Circulatory Physiology, American Physiological Society, 2010, 298 (5), pp.H1445-H1453. ⟨10.1152/ajpheart.01194.2009⟩ |
| ISSN: | 0363-6135 1522-1539 |
| DOI: | 10.1152/ajpheart.01194.2009⟩ |
| Popis: | Myocardial damages due to ischemia-reperfusion (I/R) are recognized to be the result of a complex interplay between genetic and environmental factors. Epidemiological studies suggested that, among environmental factors, carbon monoxide (CO) urban pollution can be linked to cardiac diseases and mortality. The aim of this work was to evaluate the impact of exposure to CO pollution on cardiac sensitivity to I/R. Regional myocardial I/R was performed on isolated perfused hearts from rats exposed for 4 wk to air enriched with CO (30–100 ppm). Functional variables, reperfusion ventricular arrhythmias (VA) and cellular damages (infarct size, lactate dehydrogenase release) were assessed. Sarcomere length shortening and Ca2+handling were evaluated in intact isolated cardiomyocytes during a cellular anoxia-reoxygenation protocol. The major results show that prolonged CO exposure worsens myocardial I/R injuries, resulting in increased severity of postischemic VA, impaired recovery of myocardial function, and increased infarct size (60 ± 5 vs. 33 ± 2% of ischemic zone). The aggravating effects of CO exposure on I/R could be explained by a reduced myocardial enzymatic antioxidant status (superoxide dismutase −45%; glutathione peroxidase −49%) associated with impaired intracellular Ca2+handling. In conclusion, our results are consistent with the idea that chronic CO pollution dramatically increases the severity of myocardial I/R injuries. |
| Databáze: | OpenAIRE |
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