Long-term survival outcome of laparoscopic liver resection for hepatocellular carcinoma
| Autor: | Kai-Chi Cheng, Shi Lam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Liver resection business.industry Hepatocellular carcinoma Disease-free survival medicine.medical_treatment Perioperative medicine.disease Long-term outcome Frontier Resection Surgery Systematic review Blood loss Laparoscopic hepatectomy Long term survival medicine Overall survival business |
| Zdroj: | World Journal of Gastrointestinal Surgery |
| ISSN: | 1948-9366 |
| Popis: | Long-term survival is the most important outcome measurement of a curative oncological treatment. For hepatocellular carcinoma (HCC), the long-term disease-free and overall survival of laparoscopic liver resection (LLR) is shown to be non-inferior to the current standard of open liver resection (OLR). Some studies have reported a superior long-term oncological outcome in LLR when compared to OLR. It has been argued that improvement of visualization and instrumentation and reduced operative blood loss and perioperative blood transfusion may contribute to reduced risk of postoperative tumor recurrence. On the other hand, since most of the comparative studies of the oncological outcomes of LLR and OLR for HCC are non-randomized, it remained inconclusive as to whether LLR confers additional survival benefit compared to OLR. Despite the paucity of level 1 evidence, the practice of LLR for HCC has gained wide-spread acceptance due to the reproducible improvements in the perioperative outcomes and non-inferior oncological outcomes demonstrated by large-scaled, matched comparative studies. Meta-analyses of the outcomes of these studies by multiple systematic reviews have also returned noncontradictory conclusions. On the basis of a theoretical advantage of LLR over OLR in preventing tumor recurrence, the current review aims to dissect from the current meta-analyses and comparative studies any evidence of such superiority. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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