9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells
| Autor: | Alice Bertocchi, Shiv Pillai, Hugues Allard-Chamard, W. Nicholas Haining, Kathleen B. Yates, Ian Rosenberg, Ilka A Netravali, Annaiah Cariappa |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Lineage (genetic)
Myeloid Biochemistry O-acetyl sialic acid 03 medical and health sciences chemistry.chemical_compound Mice Mice Congenic 0302 clinical medicine medicine Animals Progenitor cell 030304 developmental biology 0303 health sciences Chemistry hemic and immune systems Cell Differentiation Dendritic Cells Hematopoietic Stem Cells N-Acetylneuraminic Acid Cell biology Sialic acid Mice Inbred C57BL Haematopoiesis medicine.anatomical_structure Original Article 030215 immunology |
| Zdroj: | Glycobiology |
| Popis: | The origins of plasmacytoid dendritic cells (pDCs) have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-pDCs were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-pDCs. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the pDC lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation. |
| Databáze: | OpenAIRE |
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