An Effect of Pyridine-2-Aldoxime Methiodide (2-PAM) on Cholinesterase at Motor End-Plates

Autor: Wagley Pf, Bergner Ad
Rok vydání: 1958
Předmět:
Zdroj: Experimental Biology and Medicine. 97:90-92
ISSN: 1535-3699
1535-3702
DOI: 10.3181/00379727-97-23653
Popis: Conclusion2-PAM in a high concentration in vitro had a dual effect on motor end-plate ChE previously inactivated with TEPP. The oxime reactivated the enzyme and, if allowed to remain in contact with the preparation, inhibited the reactivated enzyme. The effect of 2-PAM was reversible and after the removal of 2-PAM no protection to ChE from the later exposure to TEPP was demonstrated.
Databáze: OpenAIRE