An Effect of Pyridine-2-Aldoxime Methiodide (2-PAM) on Cholinesterase at Motor End-Plates
Autor: | Wagley Pf, Bergner Ad |
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Rok vydání: | 1958 |
Předmět: |
chemistry.chemical_classification
Pralidoxime Compounds integumentary system biology Chemistry Motor end plates Dual effect Oxime Motor Endplate Medicinal chemistry Muscular Dystrophies General Biochemistry Genetics and Molecular Biology In vitro Pyridine-2-aldoxime methiodide chemistry.chemical_compound Enzyme stomatognathic system Picolines embryonic structures parasitic diseases biology.protein Cholinesterases Humans reproductive and urinary physiology Cholinesterase |
Zdroj: | Experimental Biology and Medicine. 97:90-92 |
ISSN: | 1535-3699 1535-3702 |
DOI: | 10.3181/00379727-97-23653 |
Popis: | Conclusion2-PAM in a high concentration in vitro had a dual effect on motor end-plate ChE previously inactivated with TEPP. The oxime reactivated the enzyme and, if allowed to remain in contact with the preparation, inhibited the reactivated enzyme. The effect of 2-PAM was reversible and after the removal of 2-PAM no protection to ChE from the later exposure to TEPP was demonstrated. |
Databáze: | OpenAIRE |
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