Design, Synthesis and Cytotoxic Evaluation of N-Acylhydrazone-Incorporated Isoxazolo[4,5-d]pyridazin-4(5H)-one Derivatives

Autor:	Keriman Ozadali‐Sari, Serenay Ceylan, Evnur Sinem Yucel, Suna Sabuncuoglu, Oya Unsal‐Tan
Rok vydání:	2022
Předmět:	Molecular Structure Bioengineering Antineoplastic Agents Gefitinib General Chemistry General Medicine Biochemistry Structure-Activity Relationship Cell Line Tumor Molecular Medicine Fluorouracil Drug Screening Assays Antitumor Molecular Biology Cell Proliferation
Zdroj:	Chemistrybiodiversity. 19(9)
ISSN:	1612-1880
Popis:	A series of isoxazolo[4,5-d]pyridazin-4(5H)-one hybrids with N-acylhydrazone structure was prepared and screened for their cytotoxic activities. The in vitro antiproliferative activity of the target molecules was evaluated against a panel of sixty cancer cell lines (NCI-60) by the National Cancer Institute. Seven of the target compounds showed prominent % inhibition against various cancer cell lines at the one-dose assay and were subsequently screened for five-dose assay. 4d, 4e and 4g (full panel mean graph midpoint GI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e50189aee25ac8f708008ac4361dff7 https://pubmed.ncbi.nlm.nih.gov/35986895 Zobrazit plný text záznamu Plný text