Hyponatremia with Persistent Elevated Urinary Fractional Uric Acid Excretion: Evidence for Proximal Tubular Injury?
| Autor: | Laura G. Sánchez-Lozada, Miguel A. Lanaspa, S-M Kurt Lee, Richard J. Johnson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Sodium Urinary system 030232 urology & nephrology chemistry.chemical_element Fructose Salt losing nephropathy 030204 cardiovascular system & hematology lcsh:RC870-923 Kidney Tubules Proximal Excretion Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipocalin-2 Internal medicine medicine lcsh:Dermatology Humans Proximal tubule Salt-losing nephropathy Aged Aged 80 and over business.industry nutritional and metabolic diseases General Medicine Middle Aged lcsh:RL1-803 medicine.disease lcsh:Diseases of the genitourinary system. Urology Endocrinology chemistry Nephrology lcsh:RC666-701 Uric acid Female Kidney Diseases Cardiology and Cardiovascular Medicine Uric acid excretion Hyponatremia business Kidney tubules |
| Zdroj: | Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 535-544 (2016) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background/Aims: Hyponatremia associated with high urinary fractional excretion of uric acid which persists after serum sodium is corrected is the cardinal feature of salt losing nephropathy (SLN). We hypothesize that low grade proximal tubular injury is present in SLN because the proximal tubule is the main site of uric acid and sodium transport. Methods: Five subjects with SLN were compared to four subjects with recurrent hyponatremia and three healthy individuals. Urinary NGAL (neutrophil gelatinase associated lipocalin, a marker of tubular injury) and fasting urinary fructose levels (a marker of proximal tubular injury) were measured. Results: Subjects with SLN (n=5) showed elevated fractional uric acid excretion (22 ± 6 vs 4 ± 2 percent, pConclusion: High urinary fractional excretion of uric acid in SLN is associated with elevated NGAL and fasting urinary fructose levels suggesting that SLN may involve tubular injury. |
| Databáze: | OpenAIRE |
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