El silicio, un posible vínculo entre la exposición ambiental y las enfermedades autoinmunes: el caso de la artritis reumatoide
| Autor: | Gladis Montoya-Ortiz, Cesar A. Speck-Hernandez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
lcsh:Diseases of the musculoskeletal system
business.industry biological alterations Immunology Autoimmune responses Environmental exposure Review Article Bioinformatics medicine.disease asbestos Medical and Health Sciences tissue injury chemistry.chemical_compound Immune system Silicone Rheumatology chemistry silica Rheumatoid arthritis silicone Medicine Orthopedics and Sports Medicine lcsh:RC925-935 business oxygen |
| Zdroj: | Arthritis Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario Arthritis, Vol 2012 (2012) |
| Popis: | Silicon is one of the most common chemicals on earth. Several compounds such as silica, asbestos, silicone or, nanoparticles are built from tetrahedral units with silicon as the central atom. Despite these, structural similarities, they have rarely been analyzed as a group. These compounds generate significant biological alterations that include immune hyperactivation, production of the reactive species of oxygen and tissue injury. These pathological processes may trigger autoimmune responses and lead to the development of rheumatoid arthritis. Populations at risk include those that constantly work in industrial process, mining, and agriculture as well as those that undergo silicone implants. Herein a review on the main features of these compounds and how they may induce autoimmune responses is presented. |
| Databáze: | OpenAIRE |
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