MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1
| Autor: | Jing Wang, Ling-Zhi Liu, Yu Yin, Zhiping Yan, Ning Liu, Bing-Hua Jiang, Chong yong Li, Xu Qian, Ying ying Wang, Ming na Li, Xie feng Wang, Peng Zhao, Yong ping You, Zhu Mei Shi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Vascular Endothelial Growth Factor A
Angiogenesis Cancer Treatment lcsh:Medicine Neovascularization Mice 0302 clinical medicine Molecular Cell Biology lcsh:Science Neurological Tumors Regulation of gene expression 0303 health sciences Mice Inbred BALB C Multidisciplinary Neovascularization Pathologic Ribosomal Protein S6 Kinases 70-kDa Glioma Vascular endothelial growth factor A Oncology 030220 oncology & carcinogenesis Medicine Epigenetics Hypoxia-Inducible Factor 1 Signal transduction medicine.symptom Cell Division Research Article Signal Transduction Transplantation Heterologous Mice Nude Biology 03 medical and health sciences Cell Line Tumor microRNA medicine Genetics Animals Humans 030304 developmental biology Cell growth lcsh:R Cancers and Neoplasms medicine.disease Molecular biology MicroRNAs Cancer research lcsh:Q Neoplasm Transplantation |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 3, p e32709 (2012) |
| ISSN: | 1932-6203 |
| Popis: | MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression, and attenuated cell proliferation, tumor growth and angiogenesis. Forced expression of p70S6K1 can partly rescue the inhibitory effect of miR-128 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future. |
| Databáze: | OpenAIRE |
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