The metabolic effects of diuron in the rat liver
| Autor: | Mellina da Silva Simões, Jurandir Fernando Comar, Lívia Bracht, Angela Valderrama Parizotto, Rosane Marina Peralta, Adelar Bracht |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Health Toxicology and Mutagenesis Mitochondria Liver Fructose 010501 environmental sciences Biology Mitochondrion Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate Internal medicine Pyruvic Acid medicine Animals Glycolysis Lactic Acid Rats Wistar Cell damage 0105 earth and related environmental sciences Pharmacology Adenosine Triphosphatases Herbicides Gluconeogenesis General Medicine Gluconeogenesis Inhibition medicine.disease 030104 developmental biology Mitochondrial respiratory chain Endocrinology Glucose chemistry Biochemistry Liver Diuron Fructolysis Pyruvic acid Energy Metabolism |
| Zdroj: | Environmental toxicology and pharmacology. 54 |
| ISSN: | 1872-7077 |
| Popis: | A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are dependent of ATP generated within the mitochondria. Conversely, it stimulated glycolysis and fructolysis, which are compensatory phenomena for an inhibited mitochondrial ATP generation. Furthermore, diuron diminished the cellular ATP content under conditions where the mitochondrial respiratory chain was the only source of this compound. Besides the lack of circulating glucose due to gluconeogenesis inhibition, one can expect metabolic acidosis due to excess lactate production, impairment of ammonia detoxification and cell damage due to a deficient maintenance of its homeostasis. Some of the general signs of toxicity that were observed in diuron-treated rats can be attributed, partly at least, to the effects of the herbicide on energy metabolism. |
| Databáze: | OpenAIRE |
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