Changes in tissue oxygen tension, venous saturation, and Fick‐based assessments of cardiac output during hyperoxia
| Autor: | Brian D. Polizzotti, John N. Kheir, Lindsay M. Thomson, James A. DiNardo, Kimberlee Gauvreau, Dorothy A. Perry, Arthur Nedder, Frank A. Pigula |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cardiac output Swine chemistry.chemical_element Hyperoxia Oxygen Fick principle Veins 03 medical and health sciences chemistry.chemical_compound Oxygen Consumption 0302 clinical medicine Fraction of inspired oxygen Internal medicine Animals Medicine 030212 general & internal medicine Cardiac Output business.industry Hyperoxemia 030208 emergency & critical care medicine General Medicine Anesthesiology and Pain Medicine chemistry Carbon dioxide Cardiology medicine.symptom business Saturation (chemistry) |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 63:93-100 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/aas.13225 |
| Popis: | BACKGROUND Hyperoxemia (arterial oxygen tension >100 mm Hg) may occur in critically ill patients and have effects on mixed venous saturation (SvO2 ) and on Fick-based estimates of cardiac output (CO). We investigated the effect of hyperoxemia on SvO2 and on assessments of CO using the Fick equation. METHODS Yorkshire swine (n = 14) were anesthetized, intubated, and paralyzed for instrumentation. SvO2 (co-oximetry) and tissue oxygen tension (tPO2 , implantable electrodes) in brain and myocardium were measured during systematic manipulation of arterial oxygen tension (PaO2 ) using graded hyperoxia (fraction of inspired oxygen 0.21 → 0.8). Secondarily, oxygen- and carbon dioxide-based estimates of CO (FickO2 and FickCO2 , respectively) were compared with measurements from a flow probe placed on the aortic root. RESULTS Independent of changes in measured oxygen delivery, cerebral and myocardial tPO2 increased in proportion to PaO2 , as did SvO2 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text