Associations between hepatitis B infection and chronic kidney disease: 10-Year results from the U.S. National Inpatient Sample
| Autor: | Xue-Mei Chen, Kai-Ju Xu, Zhong Tian, Zhou Liu, Xiao-Xia Geng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Hepatitis B virus medicine.medical_specialty Adolescent 030106 microbiology Renal function urologic and male genital diseases medicine.disease_cause Nephropathy 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Renal Insufficiency Chronic Inpatients business.industry Retrospective cohort study Hepatitis B medicine.disease Pacific islanders Female business Viral hepatitis Kidney disease |
| Zdroj: | Enfermedades Infecciosas y Microbiología Clínica. 39:14-21 |
| ISSN: | 0213-005X |
| DOI: | 10.1016/j.eimc.2020.02.029 |
| Popis: | Introduction Viral hepatitis infection is associated with negative impacts on renal function that may lead to nephropathy. We investigated associations between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) and/or end-stage renal disease (ESRD) in a large, representative sample from a nationwide U.S. database. Methods This population-based, retrospective observational study extracted data from the U.S. Nationwide Inpatient Sample (NIS) database, including adults ≥18 years old admitted to U.S. hospitals between 2005 and 2014 with records of chronic HBV infection in medical history. The final analytic sample included 70,674 HBV-infected patients and 282,696 matched non-HBV controls. Study endpoints were prevalent CKD and ESRD. Associations between CKD/ESRD and HBV and patients’ clinical characteristics were determined by logistic regression analysis. Results HBV infection was associated with slightly increased risk of prevalent CKD (OR: 1.06, 95% CI: 1.004–1.119) and an approximate 2-times risk of prevalent ESRD (OR: 1.98, 95% CI: 1.880–2.086). HBV infection in both genders was associated with slightly increased risk of CKD (males, OR: 1.09, 95% CI: 1.02–1.16; females, OR: 1.07, 95% CI: 0.98,1.17), and significantly associated with increased risk for CKD among non-diabetic patients (OR: 1.23, 95% CI: 1.15–1.32), white patients (OR: 1.14, 95% CI: 1.06–1.23) and Asian/Pacific Islanders (OR: 1.13, 95% CI: 0.98–1.30). Conclusions Chronic HBV infection is associated with slightly increased risk for CKD and greater risk for ESRD in males and females, Whites and Asian/Pacific Islanders and non-diabetic patients. |
| Databáze: | OpenAIRE |
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