Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma
| Autor: | A Khodja, S Rivoilan, Alain Latil, Rosette Lidereau, Catherine Noguès, Ivan Bièche |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Cancer Research endocrine system diseases Low oestrogen Mammary gland Loss of Heterozygosity Breast Neoplasms Biology Polymerase Chain Reaction Loss of heterozygosity Progesterone receptor Carcinoma medicine Humans skin and connective tissue diseases neoplasms Aged Aged 80 and over BRCA2 Protein Univariate analysis Genetic Alteration DNA Neoplasm Middle Aged Prognosis medicine.disease Neoplasm Proteins medicine.anatomical_structure Oncology Cancer research Female Human breast Research Article Follow-Up Studies Transcription Factors |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1997.572 |
| Popis: | To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer. |
| Databáze: | OpenAIRE |
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