Signal transduction and oncogenesis by ErbB/HER receptors
| Autor: | Mina D. Marmor, Yosef Yarden, Kochupurakkal Bose Skaria |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Receptor ErbB-2 Down-Regulation Protein Serine-Threonine Kinases Ligands Receptor tyrosine kinase Structure-Activity Relationship Growth factor receptor ErbB Neoplasms Proto-Oncogene Proteins Medicine Radiology Nuclear Medicine and imaging Protein Kinase C Insulin-like growth factor 1 receptor Radiation biology business.industry Antibodies Monoclonal JAK-STAT signaling pathway Protein-Tyrosine Kinases Enzyme Activation Oncology Type C Phospholipases ROR1 biology.protein Cancer research Mitogen-Activated Protein Kinases Signal transduction business Dimerization Proto-Oncogene Proteins c-akt Platelet-derived growth factor receptor Signal Transduction |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 58:903-913 |
| ISSN: | 0360-3016 |
| Popis: | Growth factors enable cells to escape irradiation-induced death (apoptosis). One important family of growth factors share an epidermal growth factor motif, and all bind to ErbB transmembrane receptors. In response to growth factor ligands, ErbB receptor tyrosine kinases induce a variety of cellular responses, including proliferation, differentiation and motility. Signal transduction pathways are initiated upon ligand-induced receptor homo- or heterodimerization and activation of tyrosine kinase activity. The complement of induced signaling pathways, as well as their magnitude and duration, determines the biological outcome of signaling, and in turn, is regulated by the identity of the ligand and the receptor composition. Recent insights into the structural basis for receptor dimerization, as provided by crystallographic analysis, are described, as is the differential activation of signaling pathways and downregulatory mechanisms. Further, dysregulation of the ErbB network is implicated in a variety of human cancers, and the nature of aberrant signaling through ErbB proteins, as well as current therapeutic approaches, are discussed, highlighting the role of the highly oncogenic ErbB-2 molecule. |
| Databáze: | OpenAIRE |
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