Efficient tetanus toxoid immunization on vitamin D supplementation
| Autor: | Henrik E. Mei, Andreas Radbruch, Gennadiy Drozdenko, Nadine Unterwalder, Hans-Dieter Volk, Margitta Worm, Guido Heine, Annika Lahl, Thomas Dörner |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
T-Lymphocytes Immunization Secondary Medicine (miscellaneous) Immunoglobulin G Immune system Internal medicine medicine Vitamin D and neurology Lupus Erythematosus Cutaneous Tetanus Toxoid Humans Vitamin D Nutrition and Dietetics Lupus erythematosus biology Tetanus business.industry Toxoid medicine.disease Vitamin D Deficiency Endocrinology Immunization Immunology Humoral immunity Ergocalciferols biology.protein Seasons business |
| Zdroj: | European journal of clinical nutrition. 65(3) |
| ISSN: | 1476-5640 |
| Popis: | Vitamin D mediates immunomodulatory functions, and its deficiency has been associated with an increased prevalence of immunological diseases. The supplementation of vitamin D might be therapeutically beneficial, for example, in lupus erythematosus patients. However, its affect on established recall immune responses is undefined. In all, 32 individuals were randomized in a placebo controlled, double-blind setting, and received vitamin D (daily 2000 IU) for 10 weeks followed by tetanus toxoid (TT) booster immunization. During vitamin D supplementation the median 25-hydroxyvitamin D serum concentration increased to 80.3 nM, which as expected decreased in the placebo group to 29.1 nM during the ultraviolet-deprived winter months. The TT-specific immunoglobulin G (IgG) boost efficiency was marginal higher in the vitamin D group (P=0.04). The increase of the 25-hydroxyvitamin D levels correlated with the increase of TT–IgG serum concentrations. The induction of specific serum IgA and specific antibody secreting cells was comparable between both groups. Accordingly, the TT-specific and polyclonally triggered T-cell cytokine profiles were stable as well. Vitamin D supplementation was successful and booster immunization induced efficiently specific antibodies titers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|