Nitroglycerin and propranolol on myocardial O2 consumption during myocardial ischemia
| Autor: | Herman B. Daniell |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Chronotropic
Inotrope Drug medicine.medical_specialty media_common.quotation_subject Coronary Disease Vasodilation Propranolol Nitroglycerin Coronary circulation Dogs Oxygen Consumption Coronary Circulation Internal medicine medicine Animals media_common Pharmacology business.industry Myocardium Hemodynamics Heart Peripheral medicine.anatomical_structure Lactates cardiovascular system Cardiology business circulatory and respiratory physiology medicine.drug |
| Zdroj: | European Journal of Pharmacology. 42:79-84 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(77)90193-5 |
| Popis: | The effects of i.v. and intracoronary (i.c.) nitroglycerin, i.v. propranolol, and the combination of propranolol and nitroglycerin on myocardial oxygen consumption (MVO2) and lactate utilization were studied in in situ ischemic working dog hearts. I.v. nitroglycerin reduced MVO2 9% which was associated with the peripheral vasidilatory actions of the drug. I.c. nitroglycerin which had no detectable effects on the peripheral vasculature had no significant effect on MVO2. I.v. propranolol caused an 8% reduction in MVO2 and this action was associated with a negative chronotropic and a slight negative inotropic effect. However, the combination of propranolol and nitroglycerin which was more effective than either drug alone, reduced MVO2 18% thereby indicating that the effects of the two drugs on oxygen consumption are additive. These results support the concept that the reduction of MVO2 seen with nitroglycerin is principally due to peripheral vasodilatory actions of the drug while that seen with propranolo is due to that drug's effect on the heart and the effects of the two agents are complementary. |
| Databáze: | OpenAIRE |
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