High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants
| Autor: | Albert B. Sabin, Ricardo Veronesi, Augusta K. Takeda, Expedito M. Ribeiro, Paul Albrecht |
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| Rok vydání: | 1985 |
| Předmět: |
Fever
Measles Vaccine Physiology Chick Embryo Viral Plaque Assay Antibodies Viral Measles Neutralization Tests medicine Animals Humans Immunology and Allergy Administration Intranasal Aerosols Clinical Trials as Topic biology Age Factors Antibody titer Infant Embryo Fibroblasts Hemagglutination Inhibition Tests medicine.disease Vaccination Titer Infectious Diseases Cough Child Preschool Immunology biology.protein Viral disease Measles vaccine Antibody Immunity Maternally-Acquired |
| Zdroj: | Journal of Infectious Diseases. 152:1231-1237 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/152.6.1231 |
| Popis: | Neither the presence of hypertonic sugar nor the absence of 1% human albumin in the aerosolized chick embryo fibroblast (CEF) measles vaccine was previously found to be responsible for its inadequacy in infants with titers of maternal plaque-neutralizing (PN) antibody at which human diploid cell measles vaccine was immunogenic. Eight weeks after administration of CEF measles vaccine containing 1% human albumin, antibody had developed in all 10 infants 7-10 months old and all 11 children 12-35 months old but in only 26% of 23 infants 3-5 months old and 67% of 9 infants 6 months of age. Failure of antibody development was associated with prevaccination PN antibody titers of greater than or equal to 1:50 (with one exception at a titer of 1:25). The PN antibody response to CEF vaccine (diluted 1:10, approximately 10(5) pfu/ml) in infants under seven months of age (geometric mean titer [GMT], 1:421) was significantly lower (P less than .005) than in older infants (GMT, 1:1,564). At a 1:1,000 dilution of vaccine, only 50% of 10 infants 13-25 months old, 20% of 15 infants 7-10 months old, and none of 8 infants 6 months old developed antibody. |
| Databáze: | OpenAIRE |
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